Preferably, the vaccination schedule should be completed using the same product keeping the recommended administration interval; If there are insufficient vaccines in country to complete the primary schedule with the same vaccine, one can complete the primary schedule with another vaccine of the same platform or from a different platform; For people who received a primary schedule of vaccines not used in Guatemala and have URL authorization from WHO, one can complete the primary schedule with another vaccine from the same platform or from a different platform; Information should be provided to the recipient about the possibility of increased mild adverse reactions, for which the care and surveillance guidelines for ESAVIs must be followed; The implementation of a heterologous schedule must be accompanied by a clear information campaign on the safety and effectiveness of the use of combinations of vaccines against COVID-19 by MoH.